FEATURED PUBLICATIONS

PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas.
Laimer D, Dolznig H, Kollmann K, Vesely PW, Schlederer M, Merkel O, Schiefer AI, Hassler MR, Heider S, Amenitsch L, Thallinger C, Staber PB, Simonitsch-Klupp I, Artaker M, Lagger S, Turner SD, Pileri S, Piccaluga PP, Valent P, Messana K, Landra I, Weichhart T, Knapp S, Shehata M, Todaro M, Sexl V, Höfler G, Piva R, Medico E, Ruggeri BA, Cheng M, Eferl R, Egger G, Penninger JM, Jaeger U, Moriggl R, Inghirami G, Kenner L.
Nat Med. 2012 Nov;18(11):1699-704.

ALK+ALCL induce cutaneous HMGB-1-dependent interleukin-8/CXCL8 production by keratinocytes through NF-kappaB activation.
Dejean E, Foisseau M, Lagarrigue F et al. Blood 2012

Anaplastic large cell lymphoma: the current state of play from a European prospective as presented at the second annual meeting of the European Research Initiative on ALCL, 27-28 June 2011.
Merkel O, Kenner L, Turner SD. Leukemia 2011;25:1795-1796.

Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively-parallel genomic sequencing.
Feldman AL, Dogan A, Smith DI, Law ME, Ansell SM, Johnson SH, Porcher JC, Ozsan N, Wieben ED, Eckloff BW, Vasmatzis G.
Blood. 2010 Oct 28, PMID: 21030553

Identification of differential and functionally active miRNAs in both anaplastic lymphoma kinase (ALK)+ and ALK? anaplastic large-cell lymphoma
Olaf Merkel, Frank Hamacher, Daniela Laimer, Eveline Sifft, Zlatko Trajanoski, Marcel Scheideler, Gerda Egger, Melanie R. Hassler, Christiane Thallinger, Ana Schmatz, Suzanne D. Turner, Richard Greil and Lukas Kenner
PNAS. 2010 Sep 14, PMID: 20805506

MicroRNA-16 down-regulation induces VEGF expression in anaplastic lymphoma kinase (ALK) positive anaplastic large-cell lymphoma. Leukemia.
Dejean E., M.H. Renalier, M. Foisseau, X. Agirre, GR. de Paiva, T. Al Saati, J. Soulier, C. Desjobert, L. Lamant, F. Prósper, DW. Felsher, J. Cavaillé, H. Prats, S. Giuriato, F. Meggetto. 2011.
P2011 Jul 22. doi: 10.1038/leu.2011.168. [Epub ahead of print] PMID:21778999[PubMed - as supplied by publisher]

MiR-29a down-regulation in ALK-positive anaplastic large cell lymphomas contributes to apoptosis blockade through MCL-1 overexpression.
Desjobert C, Renalier MH, Bergalet J, Dejean E, Joseph N, Kruczynski A, Soulier J, Espinos E, Meggetto F, Cavaillé J, Delsol G, Lamant L.
Blood. 2011 Jun 16;117(24):6627-37. Epub 2011 Apr 6.

Anaplastic large-cell lymphoma.
Inghirami G, Pileri SA; European T-Cell Lymphoma Study Group.
Semin Diagn Pathol. 2011 Aug;28(3):190-201