ALCL | RESEARCH GROUPS | FEATURED PUBLICATIONS | TOOLS |
Molecular Hematopathology
Group Leader:
Prof. Dr. Falko Fend / Prof. Dr. Leticia Quintanilla-Martinez
Group Members:
Dr. Irina Bonzheim
Julia Steinhilber
Janine Schmidt
Contact:
Institute of Pathology and Neuropathology
University Hospital Tuebingen
Eberhard-Karls-University
Liebermeisterstrasse 8
72076 Tuebingen
Germany
Tel. 049/7071-29-82266
Fax 049/7071-29-2258
email: falko.fend@med.uni-tuebingen.de
leticia.quintanilla-fend@med.uni-tuebingen.de
Funding:
German Research Foundation (DFG)
Description:
Role of the transcription factor C/EBPbeta in ALCL
Role of miRNAs in ALCLy
Collaborators:
Dr. L. Kenner, Vienna
Dr. L. Illert, Freiburg
Dr. Olaf Merkel, Heidelberg
Publications:
1- Next-generation sequencing identifies deregulation of microRNAs involved in both innate and adaptive immune response in ALK+ ALCL
Julia Steinhilber, Michael Bonin, Michael Walter, Falko Fend1, Irina Bonzheim, Leticia Quintanilla-Martinez. PLoS One, in press.
2- Bonzheim I, Irmler M, Klier-Richter M, et al. Identification of C/EBPbeta Target Genes in ALK+ Anaplastic Large Cell Lymphoma (ALCL) by Gene Expression Profiling and Chromatin Immunoprecipitation.
PLoS One. 2013; 8(5):e64544.
3- Illert AL, Kawaguchi H, Antinozzi C, Bassermann F, Quintanilla-Martinez L, von Klitzing C, Hiwatari M, Peschel C, de Rooij DG, Morris SW, Barchi M, Duyster J. Targeted inactivation of nuclear interaction partner of ALK disrupts meiotic prophase.
Development. 2012;139(14):2523-34.
4- Anastasov N, Bonzheim I, Rudelius M, et al. C/EBPbeta expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway. Haematologica. 2010;95(5):760-767.
Anastasov N, Klier M, Koch I, et al. Efficient shRNA delivery into B and T lymphoma cells using lentiviral vector-mediated transfer.
J Hematop. 2009;2(1):9-19.
5- Quintanilla-Martinez L, Pittaluga S, Miething C, et al. NPM-ALK-dependent expression of the transcription factor CCAAT/enhancer binding protein beta in ALK-positive anaplastic large cell lymphoma.
Blood. 2006;108(6):2029-2036.
Tools:
Diverse lymphoma cell lines and primary cases (FFPE tissue)
Techniques:
Lentiviral transduction
ChIP
miRNA mimic transfection and overexpression
Gene expression: Real time PCR, miRNA and mRNA profiling, Western Blot