ALCL     RESEARCH GROUPSFEATURED PUBLICATIONSTOOLS  
ERIA

European Research
Initiative of ALK-related
malignancies

Molecular ALK genetics in Drosophila
and mouse model systems

Group Leader:
Ruth Palmer, Professor

Group Members:
Y Yamazaki
G Wolfstetter
F Hugosson
P Mendoza Garcia

Contact:
Ruth Palmer
Professor
ruth.palmer@gu.se
Phone: +46 31 7863906+46 31 7863906
Visiting Address: Medicinaregatan 9 a, Göteborg
Postal Address: Box 440, 40530 Göteborg

Department med Biochemistry and Cellbiology (More Information)
Box 440
40530 Göteborg
Visiting Address: Medicinaregatan 9 a, 40530 Göteborg
Fax: +46 31-41 61 08
Webpage: http://www.gu.se/english/about_the_university/staff/?departmentId=035360&userId=xpalru

Funding:
Swedish Cancer Society
The Children’s Cancer Foundation
The Swedish Research Council
Lions Cancer Society, Umeå, Sweden
JC Kempe Foundation, Örnsköldvik, Sweden

Description: Our laboratory is investigating signal transduction during developmental processes employing Drosophila melanogaster and mouse model systems. Our aim is to understand the importance and function of the ALK receptor tyrosine kinase.

Collaborators: Bengt Hallberg and Suzanne Turner

Publications:
1. Hallberg, B. and Palmer RH. Mechanistic insight into anaplastic lymphoma kinase (ALK) receptor tyrosine kinase in human cancer biology.
Nature Review Cancer, Vol 13, 685-700, 2013
2. Yamazaki Y, Schönherr C, Varshney GK, Dogru M, Hallberg B, Palmer RH. Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation.
EMBO J. 2013 Feb 20;32(4):524-37
3. Popichenko D, Hugosson F, Sjögren C, Dogru M, Yamazaki Y, Wolfstetter G, Schönherr C, Fallah M, Hallberg B, Nguyen H, Palmer RH. Jeb/Alk signalling regulates the Lame duck GLI family transcription factor in the Drosophila visceral mesoderm.
Development. 2013 Aug;140(15):3156-66.
4. Chand D, Yamazaki Y, Ruuth K, Schönherr C, Martinsson T, Kogner P, Attiyeh EF, Maris J, Morozova O, Marra MA, Ohira M, Nakagawara A, Sandström PE, Hallberg B, and Palmer RH. Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma.
Dis Model Mech. 2013 Mar;6(2):373-82.
5. Englund C, Lorén CE, Grabbe C, Varshney GK, Deleuil F, Hallberg B, Palmer RH. Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion.
Nature. 2003 Oct 2;425(6957):512-6.

Weblinks: http://www.molbiol.umu.se/forskning/forskare/ruth-palmer/