Leukaemia and Lymphoma Research

Group Leader:
Suzanne Turner

Contact:
Dr. Suzanne Turner
Division of Molecular Histopathology
Lab Block Level 3
Box 231
Addenbrooke's Hospital
Cambridge
CB2 0QQ
Telephone: +44 (0)1223 762655
Email: sdt36@cam.ac.uk

Funding:
Leukaemia and Lymphoma Research Leukemia and Lymphoma Society Addenbrooke’s Charitable Trust

Description: Our research aims to dissect the initiating events in the pathogenesis of ALCL. In this regard we are examining not only the steps which occur following initial expression of the t(2;5) breakpoint product but also the cell in which this event originates.

Collaborators: Lukas Kenner, Olaf Merkel, Gerda Egger, Wilhelm Woessmann, Laurence Brugieres, Bengt Hallberg, Ruth Palmer, Carlo Gambacorti-Passerini, Justus Duyster.

Publications:
1- Turner S.D. and Alexander D.R. (2005) What have we learnt from mouse models of NPM-ALK induced lymphomagenesis?
Leukemia 19:1128-1134.
2- Youssif, C., Goldenbogan J., Hamoudi R., Viskaduraki M., Bacon, CM, Burke, A.A and Turner S.D. (2009) Genomic profiling of pediatric ALK-positive Anaplastic Large Cell Lymphoma – a Children’s Cancer and Leukaemia Group study.
Genes Chromosomes and Cancer 48(11):1018-26
3- Cui Y., Kerby A., McDuff F.K.E. and Turner S.D. (2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing malignancies.
Blood. 113(21):5217-5227.
4- Turner S.D., Yeung D., Hadfield K., Cook S.J. and Alexander D.R. (2007) The NPM-ALK Tyrosine Kinase Mimics TCR Signalling Pathways Inducing NFAT and AP-1 by Ras-Dependent Mechanisms.
Cellular Signaling. 19(4):740-47.
5- Turner S.D., Tooze R.M., Macklennan K., Alexander D.R. (2003) Vav-promoter regulated oncogenic fusion protein NPM-ALK in transgenic mice causes B-cell lymphomas with hyperactive Jun kinase.
Oncogene 22:7750-7761.

Weblinks:
http://www.path.cam.ac.uk/research/investigators/turner
http://www.cambridgecancercentre.org.uk/users/turners
http://www.immunology.cam.ac.uk/directory/sdturner

Techniques:
Functional assays
In vivo research